CRBN-ligand-716-生命科学试剂-MCE.pdfVIP

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CRBNligand-716

Cat.No.:HY-W953569

CASNo.:2925097-07-8

分⼦式:C₁₄H₁₃N₃O₅

分⼦量:303.27

作⽤靶点:LigandsforE3Ligase

作⽤通路:PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CRBNligand-716是⼀种E3泛素连接酶cereblon(CRBN)配体，⽤于募集cereblon蛋⽩。CRBNligand-716

可通过linker连接到靶蛋⽩配体上形成PROTAC。

IC50TargetCereblon

体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseand

theotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto

selectivelydegradetargetproteins.

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