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Inhibitors•ScreeningLibraries•Proteins

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D

Cat.No.:HY-125288

CASNo.:2247168-13-2

分⼦式:C₂₂H₂₈N₄

分⼦量:348.48

作⽤靶点:Ferroportin

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性D是⼀种⼝服有效的铁调素(hepcidin)⽣成抑制剂，其IC50为32nM。D在IL-6诱导

急性炎症⼩⿏模型中显著降低⾎清铁调素⽔平。D可⽤于研究铁稳态。

REFERENCES

[1].FukudaT,etal.DiscoveryofDasapotentorallyactivehepcidinproductioninhibitor:Designandoptimizationofnovel4-

aminopyrimidinederivatives.BioorgMedChemLett.2018Nov1;28(20):3333-3337.

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