Fadolmidine-hydrochloride-生命科学试剂-MCE.pdfVIP

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Fadolmidinehydrochloride

Cat.No.:HY-106388A

CASNo.:189353-32-0

分⼦式:C₁₃H₁₅ClN₂O

分⼦量:250.72

作⽤靶点:AdrenergicReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Fadolmidinehydrochloride是⼀种新型选择性α2肾上腺素受体(α2-AR)激动剂，对2A、2B和2C亚型的

EC50值分别为0.4nM、4.9nM和0.5nM。Fadolmidinehydrochloride对多种疼痛类型有效，例如热痛、机

械痛和内脏痛。此外，Fadolmidinehydrochloride还能抑制⼤⿏输精管的电刺激诱导收缩[1][2]。

IC50Targetα2-adrenergicreceptor

REFERENCES

[1].PertovaaraA.Antinociceptivepropertiesoffadolmidine(MPV-2426),anovelalpha2-adrenoceptoragonist.CNSDrugRev.2004

Summer;10(2):117-26.

[2].LehtimäkiJ,etal.Invitroandinvivoprofilingoffadolmidine,anovelpotentalpha(2)-adrenoceptoragonistwithlocalmodeofaction.Eur

JPharmacol.2008Dec3;599(1-3):65-71.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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