Exendin-4-Cys-Cy5-labeled-Exendin-4-Cys-Cy5-生命科学试剂-MCE.pdfVIP

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Exendin-4-Cys,Cy5labeled

Cat.No.:HY-13443F2

Synonyms:Exendin-4-Cys(Cy5)

分⼦式:C₂₂₅H₃₃₁N₅₅O₇₀S₄

分⼦量:5054.62

Sequence:His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Gl

u-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-

Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-{Cys-Mal-CY5}-NH2

SequenceShortening:HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-

{Cys-Mal-CY5}-NH2

作⽤靶点:FluorescentDye

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Exendin-4-Cys,Cy5labeled(Exendin-4-Cys(Cy5))是⼀种Cy5荧光团共价连接的Exendin-4(HY-13443)(⼀种

GLP-1受体激动剂)。Exendin-4-Cys,Cy5labeled实现了活体内β细胞的可视化成像，特别是在2型糖尿病模

型中评估GLP-1R的表达动态。

REFERENCES

[1].LehtonenJ,etal.Betacellspecificprobingwithfluorescentexendin-4isprogressivelyreducedintype2diabeticmousemodels.Islets.

2015;7(6):e1137415.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplicat