RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip

Cat.No.:HY-179242

分⼦式:C₄₆H₄₂F₃N₉O₃

分⼦量:825.88

作⽤靶点:TargetProteinLigand-LinkerConjugates

作⽤通路:PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip是⼀种配体-连接体，靶向RIPK1。RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip可

⽤于合成PROTACLD5097(HY-179234)[1]。

体外研究RIPK1PROTACcontainstwodifferentligandsconnectedbyalinker;oneisanE3ligaseligand,andthe

otherisforLigandsofRIPK1targetprotein(RIPK1-IN-37)(HY-179235).TheLigand-Linkerconjunction

(RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip)(HY-179242)formedbytheligationofLigandsandthelinkercanform

PROTACLD5097(HY-179234)withtheE3ligaseligand.PROTACsexploittheintracellularubiquitin-

proteasomesystemtoselectivelydegradetargetproteins[1].

REFERENCES

[1].LuD,etal.Design,Optimization,andDevelopmentofRIPK1DegraderswithImprovedPharmacokineticandPharmacodynamic

Properties.JMedChem.2025