RIPK1-IN-37-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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RIPK1-IN-37

Cat.No.:HY-179235

CASNo.:2782024-39-7

分⼦式:C₂₈H₂₇F₃N₆O₂

分⼦量:536.55

作⽤靶点:LigandsforTargetProteinforPROTAC;RIPkinase

作⽤通路:PROTAC;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性RIPK1-IN-37是⼀种RIPK1抑制剂，也是PROTAC(LD5097)靶蛋⽩的配体。RIPK1-IN-37可⽤于合成PROTAC

LD5097(HY-179234)[1]。

IC50TargetRIPK1

体外研究RIPK1PROTACcontainstwodifferentligandsconnectedbyalinker;oneisanE3ligaseligand,andthe

otherisforLigandsofRIPK1targetprotein(RIPK1-IN-37)(HY-179235).TheLigand-Linkerconjunction

(RIPK1-IN-37-CO-Ph-alkynyl-Py-Pip)(HY-179242)formedbytheligationofLigandsandthelinkercanform

PROTACLD5097(HY-179234)withtheE3ligaseligand.PROTACsexploittheintracellularubiquitin-

proteasomesystemtoselectivelydegradetargetproteins[1].

REFERENCES

[1].LuD,etal.Design,Optimization,andDevelopmentofRIPK1Degr