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G6374

Cat.No.:HY-180787

分⼦式:C₄₇H₆₆N₁₀O₅S

分⼦量:883.16

作⽤靶点:IRE1

作⽤通路:CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性G6374是⼀种IRE1PROTAC降解剂，其DC50值为0.04μM。G6374可有效诱导IRE1的泛素化和降解。

G6374可选择性抑制IRE1依赖性癌细胞的增殖[1]。

IC50TargetDC50:0.04μM(IRE1)[1]

REFERENCES

[1].DuJ,etal.Chemically-induceddegradationoftheendoplasmic-reticulumstresssensorIRE1byaVHL-recruitingchimera.Nat

Commun.2025Dec11;16(1):11445.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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