2026《去泛素化简概文献综述》2400字.docxVIP

PAGE7

去泛素化简概文献综述

泛素化是一个可逆的反应，可通过去泛素化酶（deubiquitylatingenzymes-DUB）将底物蛋白上的泛素去掉,这一过程称为去泛素化。目前发现的有100多种去泛素化酶，根据它们的域结构，DUBs可以分为五类：泛素c-端水解酶（theubiquitincarboxy-terminalhydrolases-UCHs),泛素特异性蛋白酶（theubiquitin-specificproteases-USPs),卵巢癌蛋白酶（theovariantumour-relatedproteases-OTUs),含有Machado-Joshphin区域的蛋白酶（theMachado–Josephdiseaseproteindomainproteases-MJDs)andtheJAB1/PAB1/MPN-domain-containingmetallo-enzymes(JAMMs)ADDINEN.CITEADDINEN.CITE.DATA(Nijmanetal.,2005)。JAMM家族是锌金属蛋白酶，而另外四种是半胱氨酸蛋白酶。去泛素化参与到多种生命活动中，例如基因转录，蛋白质降解，细胞周期等，同时也参与到免疫系统的调控中。

UCH家族由少量结构相关的DUB组成，能够切开泛素化短肽，并在泛素内循环中有着重要作用。其中第一个被发现的是UCH-L1,与神经退行性疾病的发展有关ADDINEN.CITEEndNoteCiteAuthorGong/AuthorYear2007/YearRecNum180/RecNumDisplayText(GongandLeznik,2007)/DisplayTextrecordrec-number180/rec-numberforeign-keyskeyapp=ENdb-id=xd0z92r055rxd8epe2cvr2tfrzeat929etz0timestamp=1597151342180/key/foreign-keysref-typename=JournalArticle17/ref-typecontributorsauthorsauthorGong,B./authorauthorLeznik,E./author/authors/contributorsauth-addressTaubInstituteforResearchonAlzheimerapos;sdiseaseandtheAgingBrain,DepartmentofPathology,ColumbiaUniversity,NewYork,NewYork,USA.bg2058@/auth-addresstitlestitleTheroleofubiquitinC-terminalhydrolaseL1inneurodegenerativedisorders/titlesecondary-titleDrugNewsPerspect/secondary-title/titlesperiodicalfull-titleDrugNewsPerspect/full-title/periodicalpages365-70/pagesvolume20/volumenumber6/numberedition2007/10/11/editionkeywordskeywordAlzheimerDisease/drugtherapy/*genetics/physiopathology/keywordkeywordDrugDeliverySystems/keywordkeywordHumans/keywordkeywordHuntingtonDisease/drugtherapy/*genetics/physiopathology/keywordkeywordMutation/keywordkeywordParkinsonDisease/*genetics/physiopathology/keywordkeywordProteasomeEndopeptidaseComplex/metabolism/keywordkeywordUbiquitinThiolesterase/genetics/*metabolism/keyword/keywordsdatesyear2007/yearpub-datesdateJul-Aug/date/pub-dates/datesisbn0214-0934(Print)#xD;0214-0934(Lin