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QND8

Cat.No.:HY-180582

CASNo.:1778682-60-2

分⼦式:C₁₅H₁₈N₄O

分⼦量:270.33

作⽤靶点:nAChR

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性QND8是⼀种选择性、强效的α7烟碱型⼄酰胆碱受体(nAChR)激动剂。QND8可减轻⾓叉菜胶诱导的炎症痛

⼩⿏的热痛觉过敏和机械痛觉过敏。QND8能够减轻⼩⿏⾜部肿胀，抑制炎症部位促炎因⼦的释放，并阻⽌⽩

细胞浸润。QND8可⽤于炎症和神经疾病的研究，如关节炎[1]。

REFERENCES

[1].WeerakulT,etal.3-(4-Hydroxyphenyl-1,2,3-Triazol-1-yl)Quinuclidine,aSelectiveα7NicotinicAcetylcholineReceptorAgonist,

AttenuatesInflammatoryPainwithaFavorableCentralNervousSystemSafetyProfileinMice[J].ACSPharmacologyTranslational

Science,2025.

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