临床试验设计的类型.ppt

临床试验设计的类型

Phasesoftrials

LectureOutline?? DiscussvarioustrialdesigntypesParallelCrossoverGroupallocationFactorialLargesimpleEquivalencyNon-inferiorityAdaptive3

ComparisonStructure:Parallel,Crossover,andGroupAllocationDesignsSectionA

ParallelDesign5

|P叫ωe G巾Randomized「占v1，白iJHSPH6

ParallelDesignExample:NETTSource:NETTResearchGroup(1999).Chest1999;116:1750-61;NETTResearchGroup(1999).JThoracCardiovascSurg,118:518-528;Fishman,A.,Martinez,F.,etal.(2023).NEnglJMed348:2059-73.?? NationalEmphysemaTreatmentTrial(NETT)- PhaseIIItrial,unmaskedPop