（共64页PPT）其他神经递质余梅.pptVIP

Ifitisproducedinexcess,orifacellisinapro-oxidantstate,nitricoxide(NO)hascytotoxiceffects.ItiswellestablishedthatNOcanreactwithsuperoxideanions(O2-;producedbyinduciblenitricoxidesynthase(iNOS)underinflammatoryconditionsorneuronalnitricoxidesynthase(nNOS),asinthecaseofexcitotoxicity)toformperoxynitrite(ONOO-),ananionwithstrongoxidantproperties1,.Asaconsequenceoftheinteractionbetweenperoxynitriteandcellularcomponents,proteinnitrationtakesplace,resultingindamagetocellularcomponents.TheNO-mediatedS-nitrosylatio