第二十章氨基酸代谢.pptx

ProteinDegradationAAMetabolism

ProteindegradationExtracellulardegradationIntracellulardegradationATP-independentoccursinlysosomesATP-dependenti)N-endruleand“PEST”sequenceii)TheroleofUbiquitin(泛素）iii)Proteasome（蛋白酶体）iiii)Highlyregulated

N-endruleAproteinshalf-lifecorrelateswithitsN-terminalresidue.ProteinswithN-terminalMet,Ser,Ala,Thr,Val,orGlyhavehalflivesgreaterthan20hours.ProteinswithN-terminalPhe,Leu,Asp,Lys,orArghavehalflivesof3minorless

PESTproteinsIthasalsobeenfoundthatproteinsrichi