单克隆抗体在血液疾病中的应用.pptVIP

CurrenttrialNHL-13:现状开始于2006,8m预期440入组(每组220例)5大洲超过20个国家美罗华在CLL中的应用TreatmentPtsCR(%)OR(%)Fludarabine20115-3285FC1103788R-FC3007295一线治疗近期疗效MJKeatingpersonalcommunication改良的R-FCreducedF(20mg/m2)andC(150mg/m2)increasedR(500mg/m2every14days,maintenanceevery3months)85%CRrate(40evaluablepatients)TarhiniJClinOncol2007;25:A2037一线治疗远期疗效1.00.80.60.40.201.00.80.60.40.20ProportionaliveR-FC(n=300)FC/FM(n=140)Fludarabine(n=190)012345678p0.001MJKeatingpersonalcommunicationSimilarPFSandOSwithF