浅谈临床抗菌药物合理应用之难点.pptVIP

Once-dailyregimenConventional(three-timesdailyregimen)Nicolauetal.AntimicrobAgentsChemother1995;39:650–655Concentration(mg/L)0814461012Time(hours)012242048162氨基糖苷:QD与TID给药MIC0AUC/MICConcentrationTime(hours)MICAUC=Areaundertheconcentration–timecurve喹诺酮类:AUC/MIC氟喹诺酮最佳AUIC（AUC/MIC)30125G+G-氟喹诺酮给药方案优化提高疗效:推荐每日一次给药Cmax/MIC?8-1024-hAUC/MIC(AUIC)G-:AUIC100-125G+:AUIC30-40防止耐药CmaxMPC争取较高的AUIC大环内酯类4种大环内酯类药物对肺炎链球菌的杀菌曲线结果表明2种酮内酯类药物Telithromycin和ABT-773呈浓度依赖性大环内酯类为时间依赖性,但其中的酮内酯类属浓度依赖性。糖肽类(a)在万古霉素2,?4,?8,?16,?和64倍M