ITP的规范化诊治.pptVIP

标准剂量美罗华治疗难治性ITP文献n给药CRPR起效时间疗效持续时间AmJHematol,2005,78:27539375mg/m2,1/w,×418%44％CR+PR者69%1-2w31%3-8w持续CR/PR的中位时间47wBrJHaematol,2004,125:23257375mg/m2,1/w,×432%54%CR+PR者94%8w内平均随访72.5w,CR者89%仍CR,PR者15%仍维持ASH2004(特发＋继发)92375mg/m2,1/w,×1-6(4次87%)46%55%40%1w，达峰时间5w36(8-168)w,CR者持续CR占69%EurJHaematol,2002,69:9512375mg/m2,1/w,×44次已达CR则停用42%75%中位随访45.7w,4/5CR32.9w-56.9w,2例PR者BPC38-148×1092例复发者复治均有效Blood,2001,98:95225375mg/m2,1/w,×420%40%OR者均在4w内,达峰时间4-8w54%OR者持续6-27个月,4例复发者复治仍有效*低剂量美罗华(100mgiv1