[分子数量遗传学课件]double-muscling genetic research.pptVIP

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2017-09-29 发布于江苏
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[分子数量遗传学课件]double-muscling genetic research.ppt

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[分子数量遗传学课件]double-muscling genetic research.ppt

Genomic analysis of monogenic traits: Positional cloning of the mh gene causing double-muscling in cattle Positional cloning of the mh gene The double-muscling phenotype Genetic determinism of double-muscling Genetic mapping of the mh gene Positional cloning of the mh gene Allelic heterogeneity of double-muscling DM: Phenotype Macroscopically: Generalized muscular hypertrophy(+25%) Reduction of size of other organs(-40%) Improved feed conversion ratio(-9%) Microscopically: Muscular hyperplasia Reduction in fat content(-40%) Reduction in connective tissue fraction Positional cloning of the mh gene The double-muscling phenotype Genetic determinism of double-muscling Genetic mapping of the mh gene Positional cloning of the mh gene Allelic heterogeneity of double-muscling DM: genetic determinism Literature Hereditary nature (obvious) Genetic determinism (controversial) Monogenic (recessive or dominant) Oligogenic Polygenic (Menissier,1982) DM: genetic determinism BBCB (Hanset Michaux, 1985ab). Segregation analysis Objective measurements of muscular development: plasma red cell creatine and creatinine content weight of individual muscles dressing out percentage price per Kg live weight, ... Family material: Experimental crosses (BBCB x Holstein/Friesian) Outbred BBCB population Positional cloning of the mh gene The double-muscling phenotype Genetic determinism of double-muscling Genetic mapping of the mh gene Positional cloning of the mh gene Allelic heterogeneity of double-muscling Genetic mapping of the mh gene Linkage mapping Linkage disequilibrium mapping Conclusions Linkage mapping Principles of linkage analysis Pedigree material Microsatellite marker maps Results Linkage mapping Principles of linkage analysis Pedigree material Microsatellite marker maps Results Pedigree material Experimental cross: the Sart-Tilman pedigree Outbred pedigrees: BBB Asturiana paternal half-sib pedigrees Pedigree material Expe