乳腺癌骨转移机制研究进展.pdfVIP

中国癌症杂志 2009年第19卷第12期 《 》 CHINA ONCOLOGY 2009 Vol.19 No.12 963 乳腺癌骨转移机制研究进展 陈慧 综述　沈赞 审校 上海交通大学附属上海市第六人民医院肿瘤内科 , 上海 200233 　　［摘要］　乳腺癌是一种容易发生骨转移的女性常见恶性肿瘤。乳腺癌细胞的特异性、骨微环境及两者间 相互作用是形成骨转移的共同因素。乳腺癌细胞表达的趋化因子受体、整合素、溶骨因子和成骨因子等使肿瘤 细胞易于扩散到骨，而骨微环境可以为肿瘤细胞的生长提供丰富的生长因子和细胞因子。一旦乳腺癌细胞侵入 骨质，肿瘤细胞分泌的因子就会作用于骨的外在结构和内在结构（如造血干细胞、T细胞、血小板、内皮细胞 等），使骨质破坏且分泌相关因子反作用于癌细胞，从而引起转移的级联反应和恶性循环形成。 　　 ［关键词］　乳腺癌；　骨转移；　分子机制 　　中图分类号：R737.9　　文献标识码：A　　文章编号：1007-3639(2009)12-0963-06 Progress in research on mechanisms of bone metastasis in breast cancer　CHEN Hui,SHEN Zan (Department of Oncology, the Sixth People Hospital, Medical College of Shanghai Jiao Tong University, Shanghai 200233, China) Correspondence to：SHEN Zan　E-mail：shenzanok@ 　　［Abstract ］ Breast cancer ranks among the most prevalent malignancies in women. Specific aspects of both breast cancer cells and the bone microenvironment contribute to the development of bone metastases. Breast cancers express chemokine receptors, integrins, cadherins, and bone-resorbing and bone-forming factors that contribute to the successful and preferential spread of tumor from breast to bone. Bone is rich in growth factors and cell types that make it a favorable environment for breast cancer cell growth. Once breast cancer cells enter the bone, breast cancer cells can secrete factors that act on bone cells and other cells within the bone, causing them to secrete factors that act on adjacent cancer cells. The steps in the metastatic cascade and the vicious cycle within bone offer unique targets for adjuvant treatments to treat and cure bone metastasis. Key words breast cancer; bone metastasis; molecular mechanisms 　［ ］　 　　乳腺癌是女性常见的恶性肿瘤，占女性恶 方法也很有限。虽然目前双磷酸盐等药物有一 性肿瘤的第1位，全世界