细胞周期蛋白依赖性激酶抑制剂的临床研究进展.pdf

Chinese Journal ofN ew Drugs 2011, 20( 14) 1 1, 2 1 1 2 , , , , ( 1山东大学药学院, 济南 250012; 2 北京大学天然药物及仿生药物国家重点实验室, 北京 100191) [] 细胞周期是细胞生命活动 重要环节, 细胞周期调控 失调与细胞癌变密切相关细胞周期 蛋白依赖性激酶( cyclindependent k inases, CDK)可促进细胞周期有序进行, 因而细胞周期蛋白依赖性激酶 抑制剂( cyclindependent k inases inhibitor, CDKI) 可以阻断细胞周期, 控制细胞增殖从而具有抗肿瘤活性 本文综述了近年来 CDK I 研究进展, 重点介绍了近年来对一些 CDK I进行 临床前或临床研究, 并展望了 CDK I 发展方向 [] 细胞周期蛋白依赖性激酶; 抑制剂; 抗肿瘤 [] R979. 1 [] A [] 1003- 3734( 2011) 14- 1280- 07 Progress in clin ical trails of cyclin dep enden t k inase inh ib itors 1 1, 2 1 1 2 HOU Xuben , FANG Hao , DU Jingtong , LIU N ing, ZHANG Liangren (1School of Pharmacy, Shandong University, Jinan 250012, China; 2StateKey Laboratory of Naturaland Biom mi etic rugs, Peking University, Beij ing 100191, China) [ Abstract] Cell cycle is a key step of a cell life, and the disorder of cell cycle can lead to the canceration. It isw ellknow n that cyclindependent k inases ( CDK) inhibitors possess the anticancer activities due to their ab ility of interrupting cell cycle and regu lating proliferation of cancer cells. Th is review summarized the recent progress of cyclindependent k inases inh ib itors, especially focused on the compounds in preclin ical or clin ical trails. [K ey w ords] cyclindependent kinase ( CDK); inhibitor; antitumor [ 1] 2001/ , , , CDK , 20 70, 3 ( cyclindependent k i ( cy nases inh ib itor, CDK I) clindependent k inases, CDK) ( cyc CDK I lins), , CDK I