经心尖国产主动脉支架瓣植入术的探索性研究.docVIP

  经心尖国产主动脉支架瓣植入术的探索性 研究# 叶赞凯1，唐跃1，王浩2，李守军1，罗富良3，夏明钰4，翁渝国5，朱晓东1* 5 10 15 （1. 中国医学科学院阜外心血管病医院心外科，北京，100037； 2. 中国医学科学院阜外心血管病医院超声科，北京，100037； 3. 中国医学科院阜外心血管病医院实验外科，北京，100037； 4. 首都医学大学宣武医院血管诊断科，北京，100053； 5. 德国柏林心脏中心） 摘要：目的 旨在研究经心尖的国产球囊扩张的主动脉瓣支架瓣膜的植入术的急性实验动物 模型。方法 使用北京美中双和医疗器械公司生产的 20mm 的球囊扩张主动脉瓣支架瓣膜在 术中超声心动图及 X 线的引导下经过心尖部植入到 6 只 30-40kg 的实验猪心脏中。均使用心 尖切口，在没有体外循环的条件下快速心室起搏的条件下置放瓣膜并评价瓣膜置放的效果。 术后通过活检病理检查确证支架瓣膜的位置。结果 5 个（83%）支架瓣膜均顺利的置放在 实验猪的正常的主动脉瓣位上，其中有 1 个（16.7%）出现瓣周漏。术中有 1 个(16.7%)支架 瓣膜发生了移位，术后均通过病理检查确证支架瓣膜的具体位置。结论 在我们这项研究中， 经心尖的国产的球囊扩张主动脉瓣支架瓣膜能够成功固定在没有病变的主动脉瓣膜上。 关键词：经心尖路径；球囊扩张 ；主动脉瓣支架瓣膜 中图分类号：R654 20 Exproratory research of Chinese ballon-expandable transapical aortic stent-prothetic valve implantation Ye Zankai1, TANG Yue1, WANG Hao2, LI Shoujun1, LUO Fuliang3, XIA Mingyu4, WENG Yuguo5, ZHU Xiaodong1 25 30 35 40 45 (1. Department of Cardiac Surgery,Fu Wai Hospital,Chinese Academy of Medical Sciences,Beijing,100037; 2. Department of Echocardiography,Fu Wai Hospital,Chinese Academy of Medical Sciences,Beijing,100037; 3. Department of Experimental Cardiac Surgery,Fu Wai Hospital,Chinese Academy of Medical Sciences,Beijing,100037; 4. Department of Vascular Ultrasound,Xuan Wu Hospital,Capital University of Medical Sciences,Beijing,100053; 5. Heart Centre in Berlin,Germany) Abstract: Objective We evaluate a transapical Chinese balloon-expandable aortic stent-prothetic valve in an experimental setting in an acute animal model.Methods A pericardial xenogranft fixed within a 20-mm stnet(Beijing ShangDaGuo Yao Medial Co.Ltd,China)was implanted using a transapical approach in 6 30-40kg pigs which were guided by intraoperative echocardiography and X-ray. A limited sternotomy was used and all the deplyments were performed on the beating heart without cardiopulmonary bypass but with rapid ventricularpacing.Results 5(83%) valves were successfully deplyed at the target site of the normal annulus,but of which peri-leak occurred in one pocedure（ 16.7%） .Valeve migration occurre