聚乙二醇单甲醚接枝改性邻苯二甲酰化壳聚糖的研究.pdfVIP

聚乙二醇单甲醚接枝改性邻苯二甲酰化壳聚糖的研究 摘 要 壳聚糖（chitosan ），是一种天然氨基多糖，属于天然高聚物，学名β- （1-4） -2-氨基-2-脱氧-D-葡萄糖，是甲壳素的脱乙酰化产物，难溶于水，而溶于酸中。 由于具有特殊的生理活性，且无毒、可生物降解、生物相容性好，壳聚糖及其衍 生物近年来在化工、环保、食品、医药、化妆品、农业等方面得到越来越广泛的 应用。壳聚糖含有羟基和氨基，具有独特的生物功能和物化性质，因此通过分子 设计可以实现受控化学修饰。聚乙二醇单甲醚接枝改性邻苯二甲酰化壳聚糖在药 物缓释、靶向施药及药物载体等方面具有良好的应用前景。但是壳聚糖的溶解、 加工过程需要一定的时间，很难满足医疗等领域的需要。通过改性可较好地解决 壳聚糖的溶解性、稳定性和加工性等问题。 本文通过官能团偶联反应，合成了聚乙二醇单甲醚接枝改性邻苯二甲酰化壳 聚糖(PLC-g-mPEG)，通过红外光谱，核磁共振谱，荧光光谱，透射电镜等方法对 其进行了化学性质的表征。合成的产物能形成自组装胶束，可以提高壳聚糖的溶 解性，有利于更好地利用壳聚糖，而且应用范围也会进一步扩大。 关键词：邻苯二甲酰化壳聚糖，自组装胶束，接枝 I 聚乙二醇单甲醚接枝改性邻苯二甲酰化壳聚糖的研究 Abstract Chitosan is a kind of natural amino polysaccharides which belongs to natural polymers and which scientific name is β- (1-4) -2- amino -2 -deoxy - D- glucose. It is the deacetylation products of chitin and difficult to dissolved in water, but can dissolve in acidic solution. As a special physical activity and non-toxic, biodegradable, biocompatible material, chitosan and its derivatives in recent years are more widely used in the chemical industry, environmental protection, food, medicine, cosmetics, agriculture and other areas. Chitosan has hydroxyl amino, includ a unique biological functions, physical and chemical properties, so through molecular design can implementation the controlled chemical modification. Phthaloylchitosan-grafted poly (ethylene glycol) methyl ether (mPEG) (PLC-g-mPEG) has a good prospect in drug delivery and targeted on the application. However, the dissolution and processing of chitosan take too much time, it is hard to meet the needs of medical and other fields. These troubles can be solution by modification. By coup