脂肪干细胞在组织工程技术治疗泌尿系统疾病中的研究现状.pdfVIP

494 Chinese Journal of Reparative and Reconstructive Surgery, April 2011, Vol. 25, No.4 · · 脂肪干细胞在组织工程技术治疗 泌尿系统疾病中的研究现状 张钦 徐月敏 【摘  要】    目的 对脂肪干细胞（adipose derived stem cells，ADSCs ）在泌尿系统疾病治疗中的研究现状进行综 述。  方法 查阅近年关于ADSCs 在膀胱修复、尿道重建、尿失禁治疗、勃起功能障碍治疗等方面的相关文献，进行综 述。  结  果 应用ADSCs 的组织工程技术治疗泌尿系统疾病，在动物实验研究中取得了显著成果，且已初步应用于临床， 并取得了良好的治疗效果。  结论 应用ADSCs 的组织工程技术有望广泛应用于泌尿系统疾病的治疗。 【关键词】    脂肪干细胞 组织工程 膀胱修复 尿道重建 CURRENT SITUATION OF ADIPOSE DERIVED STEM CELLS IN TISSUE ENGINEERING FOR TREATMENT OF UROLOGICAL DISEASES/ZHANG Qin, XU Yuemin. Department of Urology, the Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R.China. Corresponding author: XU Yuemin, E-mail: xuyuemin@263.net 【Abstract 】 Objective To review the study on adi pose derived stem cells (ADSCs) in the therapy of urological diseases. Methods The recent l iterature concerning ADSCs in bladder repair, urethral reconstruction, incontinence treatment, and erectile dysfunction treatment was reviewed. Results The application of tissue engineering using ADSCs has made significant achievements in the treatment of urological diseases and in animal studies, and has been initially used in clinical and has achieved a good therapeutic effect. Conclusion Tissue engineering using ADSCs has good prospects in the study on urological diseases, and is expected to widely used in the treatment of urological diseases. 【Key words 】    Adi pose derived stem cells Tissue engineering Bladder repair Urethral reconstruction [2] 干细胞是指具有高效增殖能力和多向分化潜能的 ADSCs ）是2001 年Zuk 等 从脂肪组织中提取的一 细胞，根据其分化潜能由高到低可依次分为全能型、多 种新的干细胞，能够向骨、软骨、心肌细胞等多个