不同剂量盐酸戊乙奎醚在老年患者全身麻醉前用药中的比较.docVIP

不同剂量盐酸戊乙奎醚在老年患者全身麻醉前用药中的比较 刘文值 朱月皓 高伦明 四川省攀枝花学院附属医院麻醉科（617000） 【摘要】 目的 比较不同剂量盐酸戊乙奎醚在老年患者全身麻醉前用药中的临床效果。方法 选择全身麻醉下行腹腔镜胆囊切除术的老年患者60例，随机分为Ⅰ、Ⅱ、Ⅲ组，每组各20例，分别于麻醉诱导前静注盐酸戊乙奎醚0.01mg/kg、0.5mg、1mg。采用VAS评分记录静注前，静注后10min、20min、30min的口干程度以及术后24～72小时副作用的发生情况。结果 三组病人性别、年龄、体重、麻醉时间、手术时间均无显著性差异（P＞0.05）；各组患者注药后30min口干程度VAS评分与基础值比较P＜0.05有显著性差异，Ⅱ组与Ⅰ、Ⅲ组比较P＜0.05有显著性差异（见表二）；术后24～72小时副作用发生率Ⅲ组与Ⅰ、Ⅱ组比较P＜0.01有非常显著性差异，Ⅰ、Ⅱ组之间比较P＞0.05无显著性差异（见表二）。结论 老年患者全身麻醉前使用盐酸戊乙奎醚以0.01mg/kg较为安全，既能有效抑制腺体分泌又能降低副作用的发生率。 【关键词】 盐酸戊乙奎醚 老年患者 术前用药 剂量 副作用 Comparison of differential dose penehyclidine hydrochloride as premedication of general anesthesia in elder patients Liu Wen Zhi Zhu Yue Hao Gao Lun Ming Department Of Anesthesiology, Affiliated Hospital Of Panzhihua College ,Panzhihua ,Sichuan 617000，China. 【Abstract】 Objective To comparison the effects of differential dose penehyclidine hydrochloride as premedication of general anesthesia in elder patients.Methods Sixty ASAⅠ～Ⅱ elder patients received general anesthesia during laparoscopic cholecystectomy (LC) were randomly allocated into three groups Ⅰ、Ⅱ、Ⅲ,each group 20 patients separately,injected intravenation with penehyclidine hydrochloride 0.01mg/kg、0.5mg、1mg separately before anesthesia introduction.The VAS of thirstiness and rate of side effect were recorded.Results There no significant difference of age,sex,body weight,anesthetic time and operative time each other(P＞0.05).Each group 30min after administration the VAS of thirstiness increased distinctly compared with basic value(P＜0.05),groupⅡ increased distinctly compared with groupⅠ and groupⅢ(＜0.05).The rate of side effect after operation in groupⅢ increased severely compared with groupⅠ and groupⅡ(P＜0.01).Conclusion It is safer injected intravenation 0.01mg/kg penehyclidine hydrochloride as premedication of general anesthesia in elder patients. 【Key words】Penehyclidine hydrochloride， Elder patients , Premedication, Dose, side effect 盐酸戊乙奎醚（以下称长托宁）作为一种新型高选择性抗胆碱药已广泛应用于各类手术的麻醉前用药。与传统的抗胆碱能药比