多种长焦区聚焦超声采集频率的人体甲状腺光声成像.docVIP

2011年中国光学学会学术年会（专题：9．生物医学光子学） 深圳 2011年9月 多种长焦区聚焦超声采集频率的人体甲状腺光声成像 曾志平1,2,3 谢文明1,2,3 李莉1,2,3 李志芳1,2,3 李 晖1,2,3* 陈树强4 （1 医学光电科学与技术教育部重点实验室，福州 350007） （2福建省光子技术重点实验室，福州 350007） （3福建师范大学物理与光电信息科技学院，福州 350007） （4 福建医科大学附属第一医院，福州 350007） * hli@ 摘要：目前临床上常规的超声成像技术在对甲状腺结节进行诊断时存在误诊和漏诊。本文研究了多种采集频率的长焦区聚焦超声换能器进行光声成像的方法。在模拟样品里埋入不同尺寸的血块用于模拟病变组织，分别采用中心频率为1 MHz、5 MHz和10 MHz的超声换能器对模拟样品进行光声成像，得到了光声层析图，然后将血液注入正常人体甲状腺腺体组织内部形成两处瘀血区，用于模拟病变甲状腺组织，并经二维扫描重构出模拟病变甲状腺组织的三维光声图像。结果表明，不同中心频率的超声换能器对不同尺寸病灶体的探测灵敏度存在较大差异，其中，5 MHz的宽带换能器对毫米量级直至几百微米大小的病灶体均具有良好的探测灵敏度，因此，获得了甲状腺及其内部两处瘀血区域的较高分辨率和对比度的3D图像，此项技术有望联合超声成像进一步提高甲状腺疾病诊断的准确率。 关键词：生物医学光子学，甲状腺三维成像，光声成像，甲状腺结节，换能器，采集频率 中图分类号：O436 Photoacoustic imaging of human thyroid based on long-focal-zone focused transducers with different frequencies Zeng Zhiping1,2,3 , Xie Wenming1,2,3, Li Li1,2,3, Li Zhifang1,2,3, Li Hui1,2,3,* and Chen Shuqiang2 (1 Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fuzhou 350007, China) (2 Fujian Provincial Key Laboratory of Photonic Technology, Fuzhou 350007, China) (3 School of Physics and OptoElectronics Technology, Fujian Normal University, Fuzhou 350007, China) (4 The First Affiliated Hospital of Fujian Medical University, Fuzhou 350007, China) * hli@ Abstract Routine ultrasound imaging of thyroid nodules in present clinic exist misdiagnosis and missed diagnosis. In this presentation, a novel method, employed a series of long-focal-zone focused transducers with different frequencies for photoacoustic imaging (PAI), is presented. Some blood clots in different sizes were embedded in tissue-mimicking phantom to be as a phantom containing specific pathological lesions. Three transducers with frequencies of 1 MHz, 5 MHz and 10 MHz were used to image this phantom photoacoustically. Different frequency photoacoustic tomographic maps were obtained. Furthermore, blood was injected into normal human thyroid tissue forming two blood stasis areas and 3D imaging was available by perform