防御素与急性肺损伤.pptVIP

Defensins Role of beta-defensin-1 in ALI Model: Pneumonia CLP in rat Intervention: Recombinant adenovirus carrying the gene encoding ?-defensin-2 , intratracheal, 48h prior Monitor: Bacteria clear, inflammation (HE ICAM), survival rate Pathological alteration of lungs Detection of ICAM in lung Level of ICAM-1 in Lung tissue Conclusion and Future ?-defensin-2 had protective role in ALI/ARDS, via both antibacterial effect and modulation of inflammation Time- Dose- dependent study, genetic association analysis will be helpful for the mechanism and function of defensins in ALI/ARDS. * 防御素与急性肺