组织工程骨软骨复合体构建的研究进展.pdfVIP

1 1120 Chinese Journal of Reparative and Reconstructive Surgery, September 2011, Vol. 25, No.9 · · 组织工程骨软骨复合体构建的研究进展 张永涛 金丹 【摘  要】    目的 对构建组织工程骨软骨复合体的相关研究进展进行综述，讨论构建中存在的不足。  方法 广 泛查阅近年来国内外有关组织工程骨软骨复合体构建研究的相关文献，并对新进展进行综述。  结果 构建组织工程骨 软骨复合体的体内研究较多，将不同组织来源的MSCs 作为种子细胞是研究热点；单相支架的应用受到限制，双相和三相 支架的研究是新趋势；生物反应器的设计和性能还需进一步优化。  结论 构建组织工程骨软骨复合体将有望成为一种 治疗软骨缺损的具有潜力的方法。 【关键词】    组织工程骨软骨复合体 MSCs 支架 生物反应器 RESEARCH PROGRESS OF CONSTRUCTION OF TISSUE ENGINEERED OSTEOCHONDRAL COMPOSITES/ ZHANG Yongtao, JIN Dan. Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China. Corresponding author: JIN Dan, E-mail: nfjindan@126.com 【Abstract 】 Objective To review the recent progress of the researches in construction of tissue engineered osteochondral composites, and to discuss the challenges in construction of tissue engineered osteochondral composites. Methods The recent l iterature on the construction of tissue engineered osteochondral composites was extensively reviewed and analyzed. Results The studies on the construction of tissue engineered osteochondral composites are relatively more in vivo, the current focus is that different tissues derived mesenchymal stem cells are widely used to be seed cells; single-phase scaffold has been limited, studies on bi phase scaffold and tri phase scaffold are new trends; the design and performance of bioreactor need to be further optimized in the future. Conclusion The construction of tissue engineered osteochondral composites will be a promising method for the treatment of cartilage defects. 【Key words 】 Tissue engineered osteochondral composite Mesenchymal stem cells Scaffold Bioreactor