万古霉素和利奈唑胺治疗MRSA的药效学比较.pptVIP

* Secondary End Point: Incidence of Nephrotoxicity (mITT Population)1 Laboratory results were generally comparable between study arms although differences were observed in the incidence of laboratory-defined nephrotoxicity (0.5-mg/mL increase in serum creatinine if normal at baseline, or 50% increase if abnormal at baseline). Renal toxicity occurred in 8.4% of linezolid-treated patients compared with 18.2% of vancomycin-treated patients in the mITT population. Renal toxicity was roughly equivalent in patients with baseline GFR 50 mL/min (13.8% linezolid vs 16.2% vancomycin), but was more than