活化T细胞核因子与肿瘤发生和发展的研究进展.pdfVIP

肿瘤 2011 年 5 月第 31 卷第 5 期　Tumor Vol. 31, May, 2011　　 469 DOI:10.3781/j .issn.1000-7431.2011.05.018 Review ·综述 活化T细胞核因子与肿瘤发生和发展的研究进展 1 2 吴　 曼 ，喻 明霞 1．武汉大学第二临床学院，武汉　430071 ；2 ．武汉大学中南医院检验科基因检测中心，武汉　430071 [摘要]　活化 T 细胞核因子 （nuclear factor of activated T cells, NFAT ）是一组在哺乳动物细胞 内广泛表达的转 录因子，主要参与精密调控机体生长发育相关的、复杂的细胞 内相互作用。近年来，越来越多的研究数据显示 NFAT 与人类肿瘤的发生、发展密切相关在多种肿瘤细胞及肿瘤微环境的复杂间质成分中，NFAT 异常活化，促 进肿瘤形成和浸润转移。本文旨在阐述 目前研究发现的 NFAT 在肿瘤生物学中发挥的重要作用，涉及肿瘤的形成、 生长、存活、恶性转化、侵袭转移和血管生成等过程，以及 NFAT 在肿瘤发生、发展中的作用机制，预测这些研 究结果对于开辟新的肿瘤治疗途径有着重要的意义。 [关键词]　肿瘤 ；活化T 细胞核因子；转录因子；肿瘤转移 [中图分类号]　R73-3; R730.23 1 [文献标志码] A [文章编号]　1000-7431(2011)05-0469-05 Potential role of nuclear factor of activated T cells in cancer progression 1 2 WU Man , YU Ming-xia 1. Second Clinical Medicine College; 2. Department of Clinical Laboratory Science Genetic Testing Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, China [A BSTRACT]　The nuclear factor of activated T cells (NFAT)—a group of transcription factors ubiquitously expressed in mammalian tissues, plays a critical role in orchestrating the intricate cellular interactions that characterize vertebrate development and morphogenesis. Recently, accumulated evidence points to an emerging role for NFAT transcription factors in cancer progression. Various NFAT isoforms are remarkably functional in tumor cells and multiple compartments in the tumor microenvironment, promoting carcinogenesis and cancer invasion. This review highlights the current knowledge about the role of NFAT in oncobiology, including tumor generation, growth, survival, malignant transformation, invasion, metastasis and angiogenesis. Clarifying the parts played by NFAT in tumor progression will help the development of effective therapeutics that target the