microRNA-155研究进展.pdfVIP

第22卷 第2期 生命科学 Vol. 22, No. 2 2010年2月 Chinese Bulletin of Life Sciences Feb., 2010 文章编号 ：1004-0374(2010)02-0139-04 microRNA-155研究进展 李　江，胡维新* (中南大学生物科学与技术学院分子生物研究中心，长沙 410078) 摘 要：microRNAs(miRNAs)是一类进化上保守的非编码单链小RNA，长19～24 个核苷酸，能在转录 后降解靶基因mRNA 或抑制基因的翻译。microRNA-155(miR-155)具有多种生物学功能，它能影响造血 细胞的分化，并在炎症反应、免疫反应中发挥重要作用。大量研究表明，miR-155 在多种肿瘤细胞中 过表达，推测其与肿瘤的发生发展密切相关。随着研究的深入，miR-155 可能成为新的肿瘤标志物及 肿瘤基因治疗的新靶点。 关键词：miR-155；造血细胞；炎症反应；免疫反应；肿瘤 中图分类号：Q71；R730.231　　文献标识码：A The progress of microRNA-155 research LI Jiang, HU Wei-xin* (Institute of Molecular Biology, School of Biological Science and Technology, Central South University, Changsha 410078, China) Abstract: microRNAs (miRNAs) are a class of evolutionarily conserved, single-stranded, non-coding RNA molecules consisting of 19~24 nucleotides, which can degrade mRNA of target gene after transcription or suppress gene translation. Recently, miR-155 is proved as a typically multifunctional miRNA that influences the differen- tiation of hematopoietic cells, and plays an important biological role in inflammatory and immune response. A large number of studies have shown that miR-155 over-expresses in a lot kinds of tumor cells, suggesting it might be involved in the occurrence and development of tumors. We propose that miR-155 is likely to be a novel tumor marker and a potential application of tumor gene therapy. Key words: miR-155; hematopoietic cells; inflammatory response; immune response; tumor microRNAs(miRNAs)是一种类似于siRNA，长 降解mRNA或抑制靶基因的翻译。1993年，Lee等[1] 19～24个核苷酸，内源性非编码蛋白质的小RNA分