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22 1 Vol. 22, No. 1
2010 1 Chinese Bulletin of Life Sciences Jan., 2010
1004-0374(2010)01-0074-05
(LCR)
(100029)
β(locus control regions LCR)
LCR 6~25 kb7
DNaseI LCR
LC R
DNA LCR
(looping model) (GH)TH2
MHC II LCR
LC R β
Q 75 8 A
Gene expression regulated by locous control region
WANG Hai, RUAN Xiu-yan, FANG Xiang-dong*
(Key Laboratory of Genome Science and Information, Beijing Institute of Genomics,
Chinese Academy of Sciences, Beijing 100029, China)
Abstract:The locus control region (LCR) was first identified in the human β globin locus. It plays an important
role of regulating gene expression in differentiation and development of erythrocyte. The LCR is located 6 - 25 kb
upstream of the first globin gene and consists of 7 DNase I hypersensitive sites. The most prominent property
of the LCR is their strong transcription-enhancing activity. LCR can also participate in histone modification,
chromatin ‘open’, nuclear localization, domain boundaries formation, and timing and origin of DNA replication.
Four models of LCR function have been proposed, while most of the experimental results support the looping
model. Besides in β globin locus, LCRs are found in the loci of growth hormone, TH2 cytokine, MHCII and many
other genes.
Key words:LCR; transcriptional regulation; β globin locus
(locus control regionsLCR) DNase I
DNA (hypersensitive siteHS)
DNA
DNase I 200~300 bps LCR
DNase I HS [1]
DNase I LCR β
DNA DNA
2009-06-30 2009-09-17
DNase I
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