寒凝血瘀心肌缺血动物模型的建立和评价研究.pdfVIP

82 中药药理与l临床 2009；25(4) 10 NogueraAguilarJF，I．AmengualAntieh，A．PlazaMartlnez，eta1． cancercells．BiolPharmBull，2001；24(8)：917 Cyelooxygenase-2inhibition incolonexperimentaleareino—genesis．RevEsp 13 OgasawaraM ．SuzukiH．inhibitionbyevodiamineofhepatocytegrowth EnfermDig．2005；97(9)： 637～647． factor—induced invasion andmigration oftumorcells ．BiolPharm Bull， 1l 郑树，主编．结直肠癌肿瘤．北京：人民卫生出版社．第 1版，2006 2004；27(4)： 578 ： 404 14 FearonER，VogelsteinB．Ageneticmodelforcolorectaltumorigenesis． 12 OgasawaraM，MatsubaraT，SuzukiH，eta1．inhibitoryeffectsofevodi— Cell，1990；61(5)：759—767 amineoninvitroinvasionandexperimentallungmetastasisofmurinecolon Established colorectalcarcinomamodelinratstoinvestigateanti-colorecaticarcinomaactifities ofZuojinPill(左金丸)andFanzuojinPlil(反左金丸) W enBin。 HuangQiulin ，XiongMingli，DaiWeiyi，LiangQiheng，LiuLing，GongYanqing’ ， (。InstituteofPiwei，GuangzhouUniversityofChineseMedicine，Guangzhou 510405； GuangzhouUniversityofChineseMedicalSecondClinicalSchool，Guangzhou 510405) Objective：ToestablishcolorectalcarcinomamodelinratsandinvestigatetheinterventionofZuojinPillandFanzuojinPilloffthepro- gressivecolorcetal carcinoma．M ethods：ThenudemicetransplantedHT29cellsandtheDMH inducedratcolorcetalcarcinomamodelwere established．NudemiceandratswererandomlydividedintoZuojinpillgroup，Fanzuojinpillgroupandcontrolrgoup．NudemicewerekiUed after5weekstreatment，tumorsizewasdetected．Ratswererandomlydividedintotwogroups：A(DMH：35mg／kg)andB (DMH：25mg／ kg)，AandBwererandomlydividedintoZuojinpillrgoup，Fanzuojinpillgroupandcontrolrgouprespectively．AandBkilledrespectively after11，21，24，34weekstreatment。ToobservethescheduleoftumordevelopmenteffectedbyZuojinpillandFanzuojinpil1．Results： ZuojinpillandFanzuojinpillcanrcpresstheinv