载药纳米仿生骨治疗骨缺损伴骨髓炎的研究进展.pdfVIP

356 Chinese Journal of Reparative and Reconstructive Surgery, March 2010, Vol. 24, No.3 · · • 综 述 • 载药纳米仿生骨治疗骨缺损伴骨髓炎的研究进展 1 1 2 弓家弘 王静成 王大新 【摘  要】 目的 对载药纳米仿生骨治疗骨缺损伴骨髓炎的研究进展进行综述，为相关研究提供理论基础与实验 参考。 方法 查阅国内外相关文献，对载药纳米仿生骨治疗骨缺损与骨髓炎的研究现状进行分析。综述载药纳米仿生 骨的设计与制备方法，骨缺损与骨髓炎动物模型的制作以及该研究的大体步骤、检测指标与效果评价。 结果 创伤性 骨髓炎与骨缺损是临床骨科难以治疗的两大疾病，许多研究者使用纳米级材料制作仿生骨，并通过不同方法在其中加入 药物，以期同时治疗感染并修复骨缺损，但研究总体仍处于实验室阶段，且缺乏相关动物模型的制作标准，在药物缓释及 仿生骨制备方法上还需进一步改良。 结论 载药纳米仿生骨在多项治疗动物骨髓炎与骨缺损的研究中均取得了较好 的效果，有望作为一种新兴的骨替代材料。 【关键词】 载药纳米仿生骨 骨缺损 骨髓炎 中图分类号： R681.2 R318.08 文献标志码：A RESEARCH PROGRESS IN TREATMENT OF BONE DEFECT WITH OSTEOMYELITIS BY USING DRUG- 1 1 2 1 CARRIED BIONIC NANO-BONE/ GONG Jiahong , WANG Jingcheng , WANG Daxin . Department of Orthopaedics, 2Medical Tissue Engineering Research Center, Subei People’s Hospital of Jiangsu Province, Yangzhou Jiangsu, 225001, P.R.China. Corresponding author: WANG Jingcheng, E-mail: 001wjc@ 【Abstract 】    Objective To review the research progress in the treament of bone defect or osteomyel itis with drug-carried bionic nano-bone so as to offer some theoretic supports and experimental references for those relative researchers. Methods The related l iterature was reviewed. The research progress in the treatment of bone defect or osteomyelitis with drug-carried bionic nano-bone was analyzed, which included the designing and preparing of drug-carried nano composites, the way of making infected bone defect animal models, and the general steps, test indexes and results. Results Traumatic osteomyelitis and bone defect were two kinds o