苦参素葡萄糖注射液在肝血管瘤化疗期间防肝损伤效果分析.pdfVIP

窑药物与临床 窑 2013年4月第10卷第 11期 苦参素葡萄糖注射液在肝血管瘤化疗期间 防肝损伤效果分析 王青蓝 山东省莱芜市人民医院肿瘤科袁山东莱芜 271100 [摘要] 目的分析苦参素葡萄糖注射液在肝血管瘤化疗期间防肝损伤的效果遥 方法选取莱芜市人民医院2009年 3月耀2012年9月收治的32例肝血管瘤患者袁 采取自身对照的方法袁 所有患者均给予两个阶段相同的化疗方 案袁第 1阶段仅给予化疗药物进行治疗袁而不给予保肝药物袁处于本阶段的患者称之为对照组曰第2阶段在第1阶 段给予化疗药物的基础上袁再应用苦参素葡萄糖注射液进行保肝治疗袁处于本阶段的患者称之为研究组遥 待两 组患者在各自的化疗方案结束后袁观察比较两组的肝功能情况遥 结果对照组出现肝功能损害 17例渊53.1%冤袁 研究组出现肝功能损害8例渊15.6%冤袁差异有统计学意义渊P约0.05冤遥研究组患者的肝功能损害程度明显低于对 照组袁差异有统计学意义渊P约0.05冤遥 两组在各自的化疗前袁检测获得的丙氨酸氨基转移酶渊ALT冤尧碱性磷酸酶 渊AKP冤和酌-谷氨酰胺渊酌-GT冤含量差异无统计学意义渊P 跃 0.05冤曰在化疗后袁研究组的ALT尧AKP和酌-GT含量 明显低于对照组袁差异有统计学意义渊P约0.05冤遥 结论对于肝血管瘤患者袁在其化疗期间应用苦参素葡萄糖注 射液能起到预防肝脏损害的功效袁保肝效果较为满意袁值得进一步推广遥 [关键词]苦参素曰肝血管瘤曰化疗曰预防曰肝功能 [中图分类号] R735.7 [文献标识码]A [文章编号] 1673-7210渊2013冤04渊b冤-0066-02 Effect analysis of anti liver damage of Oxymatrine Glucose Injection in hepatic hemangioma duringchemotherapy WANG Qinglan Departmentof Oncology,LaiwuPeoples Hospital,ShandongProvince,Laiwu 271100, China [Abstract] Objective To analyze the effects of anti liver damage of Oxymatrine Glucose Injection in hepatic heman鄄 gioma during chemotherapy. Methods 32 cases of patients with hepatic hemangioma admitted to Laiwu Peoples Hos鄄 pitalfrom March2009to September2012were includedfor self-controlstudy.All patientswere treated with the same chemotherapyregimen intwo stages. Inthefirst stage,patientswere given chemotherapywithout hepatoprotective drug andwere referred to asthe control group; in the second stage, patientswere given Oxymatrineto protect liver in addi鄄 tion to the same treatment given in stage two and were referred to as the study group. Liver functions of both groups were observed and compared after treatment. Results There were 17 cases (53.1%) of liver dam