BMP-6成骨机制和成骨效应研究进展.pdfVIP

1144 Chinese Journal of Reparative and Reconstructive Surgery, September 2013, Vol. 27, No.9 · · BMP-6 成骨机制和成骨效应的研究进展 许刚 张长春 周建生  黄震 孟红亚 【摘  要】 目的 综述BMP-6 的成骨机制和成骨效应，为其进一步研究提供参考。 方法 广泛查阅近年国内外 有关BMP-6 成骨机制及其在动物实验中成骨效应的文献，并进行归纳总结。  结果  BMP-6 由骨基质产生，通过Smad 蛋白信号转导途径将成骨信号转导至BMSCs ，诱导其向成骨、成软骨方向分化，并在骨和软骨的发育成熟过程中起重要作 用；BMP-6 还与多种骨病（如骨折、骨质疏松、骨肿瘤）有密切关系。 结论 对BMP-6 的深入研究有望为临床治疗骨折 不愈合、骨关节炎、骨质疏松症等相关骨病提供一条新途径。 【关键词】 BMP-6 成骨机制 成骨效应 ADVANCES IN OSTEOGENIC MECHANISM AND OSTEOGENIC EFFECTS OF BONE MORPHOGENETIC PROTEIN 6/XU Gang, ZHANG Changchun, ZHOU Jiansheng, HUANG Zhen, MENG Hongya. Department of Orthopaedics, the First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui, 233004, P.R.China. Corresponding author: ZHANG Changchun, E-mail: zccanhui@ 【Abstract 】 Objective To review the osteogenic mechanism and osteogenic effects of bone morphogenetic protein 6 (BMP-6) so as to provide the basis for further research of BMP-6. Methods The related articles about the osteogenic mechanism and the osteogenic effects of BMP-6 in experimental animals were extensively summarized. Results BMP-6 from bone matrix can transduct the osteogenic signal to bone marrow mesenchymal stem cells (BMSCs) by means of Smad protein signal transduction pathway. And the BMSCs which received the signals will differentiate into osteoblasts and chondroblasts. Therefore, BMP-6 plays an important role in the development and maturation of bone and cartilage. In addition, BMP-6 has a close relation with bone diseases, such as fracture, osteoporosis, and bone tumor. Conclusion The deep research of BMP-6 is expected to provide a new therapeutic approach for treating bone diseases of nonunion, osteoarthritis, and osteoporosis. 【Key words 】 Bone morphogenetic protein 6 Osteogenic mechanism Osteogenic effect