病理学 8年制2版01适应和细胞损伤.pptVIP

含铁血黄素 肺CPC，含铁血黄素 肺CPC，含铁血黄素，Fe 胆汁与胆色素 胆汁与胆色素 肝血色病 Idiopathic hemochromatosis Pathologic calcification Dystrophic calcification Metastatic calcification Dystrophic calcification In areas of necrosis as fine white granules or clumps. Intracellular or extracellular, or in both. Heterotopic bone may be formed. Psammoma bodies. 冠状动脉钙化 Summary Reversible cell injury swelling; fat change Irreversible cell injury necrosis; apoptosis Patterns of necrosis coagulative necrosis; liquefative necrosis specific necrosis Intracellular accumulation A normal cellular constituent accumulated in excess, (e.g. Water, lipid, protein, carbohydrates) An abnormal substance: exogenous endogenous Pigment Intracellular accumulation A normal endogenous substance, but the rate of metabolism is inadequate to remove Genetic or acquired defects in metabolism, packaging, transport or secretion -- storage disease, alpha-1-antitrypsin deficiency An abnormal exogenous substance is deposited due to the cell unable to degrade or transport it to other sites Lipids Steatosis (fatty changes) clear vacuoles in liver, heart Cholesterol and cholesterol esters Atherosclerosis Xanthomas Inflammation and necrosis Cholesterolosis Proteins As round, eosinophilic droplets, vacuoles or aggregates in the cytoplasm. Accumulation of cytoskeletal proteins Amyloidosis Reabsorption droplets in proximal renal tubules Synthesis of excessive amounts of normal secretory proteins —— Russell bodies in plasma cells Defects in protein folding Defects in protein folding Defective intracellular transport and secretion of critical proteins a-1-antitrypsin deficiency cystic fibrosis Toxicity of aggregated, abnormally folded proteins neurodegenerative diseases (proteinopathies or protein-aggregation disease) Amyloidosis of the liver is characterized by homogeneous eosinop