3.0T场强PCASL和多b值扩散加权成像在皮层下脑梗塞的应用初步研究2.docx

3.0T场强PCASL和多b值DWI在脑梗死的应用初步研究Preliminary application of PCASL and multi-b-value?DWI?at 3.0T MR imaging in subcortical cerebral infarction罗海龙，黄力，凌雪英，王颖，肖泽宇，余奕滨【摘要】目的 探讨3.0T 场强 MR 动脉自旋标记灌注（ASL）和双指数多b值扩散加权成像（DWI）在皮层下脑梗死的应用价值。方法 对13例皮层下脑梗死病人行ASL、常规DWI，0s/mm2-4000s/mm2 之间共12个b值DWI扫描，并对多b值DWI按照双指数模型拟合。对比梗死灶和镜像对照区之间rCBF、ADC、D、D*、fD*差异，并对比rCBF和D、D*、fD*，ADC和D、D*、fD*的相关性。结果梗死灶rCBF下降（p0.001），ADC、D、fD*升高（p0.001）。rCBF和fD*存在相关性（p=0.05、r=0.58），但和D、D*无明显相关性；ADC和D存在相关性（p0.001、r=0.92），但和D*、fD*无明显相关性。结论 在3.0T设备应用PCASL能够有效的显示脑梗死的灌注改变，包括深部脑组织灌注改变。双指数模型多b值DWI的D能够反映脑组织的扩散改变，但D*仍不足以用于灌注测量。【Abstract】Purpose: To investigate the feasibility of arterial spin labeling perfusion and biexponential multi-b-value DWI in cerebral infarction at 3.0T MR. Materials and methods: 13 patients with cerebral infarction patients with ASL, DWI and multi-b-value DWI scans. The multi-b-value DWI was applied using a biexponential model with 12 b values between 0s/mm2-4000s/mm2. Difference of rCBF, ADC, D, D *, fD * between infarct area and the mirror control were compared. Correlation of rCBF and D, D *, ADC and D *, fD * were investigated. Results: rCBF of infarction decreased. ADC, D, fD * of infarction increased. Correlation between rCBF and fD * (p = 0.049, r = 0.58) had statistically significant but not be seen in rCBFvsD and rCBFvsD *. Correlation between ADC and D had statistically significant(p0.001, r=0.92) but not be seen in ADCvsD and ADCvsfD*. Conclusion: PCASL can effectively display cerebral perfusion change in 3.0T MR, including changes in deep brain tissue perfusion. D of biexponential multi-b-value DWI reflected changes of diffusion, while D * is still not adequate for perfusion measurements.【关键字】伪连续动脉自旋标记灌注、多b值、扩散加权成像、双指数模型、脑梗死【keyword】 PCASL, multi-b-value, DWI, biexponential model, cerebral infarction脑梗死是一种致残率、致死率较高的常见病,在脑梗死的临床诊治，二级预防以及基础研究中，影像学都是其不可或缺的重要内容。随着影像学技术的发展，越来越多的新技术应用于脑梗死的临床和基础研究，不仅可以提供脑梗死组织的解剖信息，还有助于了解病变组织的微循环和代谢情况。动脉自旋标记（arterial spin labeling，ASL）灌注成像是一种磁共振灌注技术，通过在血流上游层面（标记层）对流入