肥胖位点解读-4.pptVIP

Leptin and insulin (lower part of the figure) circulate in the blood at concentrations proportionate to body-fat mass. They decrease appetite by inhibiting neurons (centre) that produce the molecules NPY and AgRP, while stimulating melanocortin-producing neurons in the arcuate-nucleus region of the hypothalamus, near the third ventricle of the brain. NPY and AgRP stimulate eating, and melanocortins inhibit eating, via other neurons (top). Activation of NPY/AgRP-expressing neurons inhibits melanocortin-producing neurons. The gastric hormone ghrelin stimulates appetite by activating the NPY/AgRP