肥胖者内脂素基因多态性对糖脂代谢及运动减肥效果的影响.pdfVIP

96 生理学报Acta Physiologica Sinica , February 25, 2012, 64(1): 96–100 综 述 肥胖者内脂素基因多态性对糖脂代谢及运动减肥效果的影响 1,* 2 赖爱萍 ，陈文鹤 1 311231 2 200438 浙江体育职业技术学院体育系，杭州 ；上海体育学院运动科学学院，上海 摘 要：内脂素(visfatin)，又被称为尼克酰胺磷酸核糖转移酶(nicotinamide phosphoribosyl transferase, NAMPT)，是由脂肪组 织分泌的细胞因子，在体内进行免疫调节，还可以作为NAMPT调节NAD+补救途径，同时也可影响糖脂代谢及运动减肥效 果。本文旨在对肥胖者内脂素基因多态性与糖脂代谢及运动减肥效果的相关研究进行综述。 关键词：内脂素；基因多态性；糖脂代谢；运动干预 中图分类号：G804.7 Effects of visfatin gene polymorphisms on glycolipid metabolism and exercise- induced weight reduction in obesity LAI Ai-Ping1,*, CHEN Wen-He2 1Physical Education Department of Zhejiang College of Sports, Hangzhou 311231, China; 2School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China Abstract: Visfatin, also named nicotinamide phosphoribosyl transferase (NAMPT), is a cytokine secreted from adipose tissue. Visfa- tin can regulate immune action and is involved in the NAD+ salvage pathway. In addition, recent researches have shown that visfatin helps the regulation of glucose and lipid metabolism, especially in exercise-induced weight reduction for obesity. The aim of this re- view is to provide an overview of the contribution of visfatin gene polymorphisms to glucose and lipid metabolism and exercise- induced weight reduction in obesity. Key words: visfatin; gene polymorphisms; glucose and lipid metabolism; exercise [1] 2 (type 2 diabe- 肥胖被认为是低度的炎症反应状态 ，目前肥 可能在肥胖相关的IR 和 型糖尿病 胖的患病率不断上升，据估计至2030 年全球将有 tes mellitus) 发病机理中发挥着重要作用。继第一代 11.2 亿肥胖者[2] ，而肥胖伴随的糖脂代谢紊乱，如 限制性片段长度多态性(restriction fragment length 胰岛素抵抗(insulin resistance, IR)、血脂代谢异常 polymorphism, RFLP) 标记、第二代微卫星多态性标 等所带来的健康风险日益增加。因此，肥胖已经成 记之后，单核苷酸多态性(