榄香烯联合氟脲嘧啶-紫杉醇治疗进展期胃癌的临床观察.DOCVIP

临床医学论文-榄香烯联合氟脲嘧啶/紫杉醇治疗进展期胃癌的临床观察 【摘要】? 　　目的 观察榄香烯乳联合氟脲嘧啶/紫杉醇治疗进展期胃癌的临床疗效。 方法 60例进展期胃癌随机分为两组，各30例。单纯化疗组：紫杉醇175mg/m2 静滴 第1天，加5-Fu 400mg/m2 静推 第1～2天，加亚叶酸钙 200mg/m2 静推 第1～2天，加5-Fu600mg/m2 维持22h 第1～2天, 21d为1个周期，共4～6个周期。联合化疗组：化疗方案同单纯化疗组，另加榄香烯600g静滴第1～14天。观察两组病人疗效、不良反应、免疫功能和生活质量改善情况。 结果 联合化疗组有效率56.7%,单纯化疗组有效率50%；疾病进展时间联合化疗组(6.99±1.76)个月，单纯化疗组(6.25±1.65)个月；平均生存时间联合化疗组(11.38±2.14)个月，单纯化疗组(10.62±1.44)个月。疾病进展时间和平均生存时间，两组差异均无显著性。联合化疗组3～4度中性粒细胞减少、白细胞总数减少、神经毒性反应均低于单纯化疗组(P0.05)。生活状况改善率联合化疗组80%，单纯化疗组53.4%，差异有显著性(P0.05)。CD3、CD4及CD4/CD8，在2个周期化疗后，两组差异有显著性(P0.05)。 结论 榄香烯乳联合氟脲嘧啶/紫杉醇化疗治疗进展期胃癌,能够减轻化疗毒副作用，改善生活质量，提高免疫功能。 【关键词】? 进展期胃癌 榄香烯 化疗 不良反应 　　【Abstract】? Objective? To study the therapeutic effects of treating progressive gastric cancer with Elemenum Emulsion combined with Fluorouracil/Paclitaxel. Methods?? 60 patients of progressive gastric cancer were divided into 2 groups randomly with 30 in each ,one with single chemotherapy : Paclitaxel 175mg/m2 i.v. drop ,day 1 , 5-Fu 400mg/m2 day 1-2, Calcium Folinate 200mg/m2 i.v.,day1-2, 5-Fu 600mg/m2 civ 22h ,day 1-2, every 3 weeks′4 cycles, the other group was combination chemotherapy group , the chemotherapy was the same ,plus Elemenum Emulsion 600g i.v. drop ,day 1- 14. The therapeutic effect 、side effect 、change of immune function and life quality were observed .Results? The effective rate was 56.7% in combination chemotherapy group and 50% in single chemotherapy group ;time to disease progression was (6.99±1.76) months in combination chemotherapy group and 6.25±1.65 in single chemotherapy group . There was not significant difference in time to progression and average live time between the two groups . Incidence of grade 3/4 neutropenia、leucocytopenia、neurotoxic reaction were all lower in combination chemotherapy group than those in single chemotherapy group (P0.05).The rate of life quality improvement was 80% in combination chemotherapy group and 53.4% in single chemotherapy group (P0.05).There was significant difference in CD3、CD4、CD4 a