奥美拉唑、呋喃唑酮、阿莫西林三联疗法治疗幽门螺杆菌相关性消化性溃疡的疗效观察.DOCVIP

临床医学论文-奥美拉唑、呋喃唑酮、阿莫西林三联疗法治疗幽门螺杆菌相关性消化性溃疡的疗效观察 【关键词】? 消化性溃疡 ??? 【摘要】? 目的? 观察奥美拉唑、呋喃唑酮、阿莫西林三联疗法对消化性溃疡（PU）的治疗效果及幽门螺杆菌（Hp）的根除效果。方法? 对64例幽门螺杆菌阳性的消化性溃疡患者，随机分为治疗组及对照组。治疗组33例，给予奥美拉唑20mg，每日1次，呋喃唑酮100mg，每日2次；阿莫西林1000mg，每日2次，饭前服用1周；对照组31例，给予奥美拉唑20mg，每日2次，克拉霉素500mg，每日2次，阿莫西林1000mg，每日2次，饭前服用1周；停药4周后复查胃镜。结果? 治疗组与对照组Hp根除率分别为90.9%、93.5%，差异无显著性（P＞0.05）；溃疡愈合率分别为93.9%、96.8%，差异无显著性（P＞0.05）。结论? 奥美拉唑、呋喃唑酮、阿莫西林三联疗法具有疗程短、疗效高，依从性好、费用低，值得基层医院推广应用。 　　【关键词】? 消化性溃疡;幽门螺杆菌;奥美拉唑;克拉霉素;呋喃唑酮;阿莫西林;三联疗法?? 　　A study on the effect of triple therapies with omeprazole,furazolidone and amoxicillin in peptic ulcer relevant to Helicobacter pylori 　　【Abstract】? Objective? To study the effect of triple therapies with omeprazole,furazolidone and amoxicillin in peptic ulcer （PU ）and elimination to Helicobacter pylori （Hp ）.Methods? 64 patients with peptic ulcer were assigned to 2 groups at random:the treatmetn group with 33 patients and the control group with 31 patients,the treatmetn group received omeprazole 20mg qd,furazolidone 100mg bid and amoxicillin 1000mg bid.While the control group was treated with omeprazole 20mg qd,clarithromycin 500mg bid and amoxicillin 1000mg bid. All treatment lasted one week.After stopping treat 4 weeks,every patient rechecked gastroscope.Results牋 The elimination ratio of the treatment group and the control group were 90.9% and 93.5%,there was no diffierence between them(P＞0.05). The cure ratio of two groups were 93.9% and 96.8%.There was no diffierence between them too(P＞0.05).Conclusion? The triple therapies with omeprazole,furazolidone and amoxicillin is worth spreading in basement with shore course of treatment,good curative effect,easy compliance and low expense. 　　【Key words】? peptic ulcer;Helicobacter pylori;omeprazole;clarithromycin;furazolidone;amoxicillin;triple therapies 　　近年来研究表明，幽门螺杆菌（Hp）是消化性溃疡（PU）致病及复发的主要原因之一，根除Hp能促进PU愈合。笔者对33例幽门螺杆菌阳性消化性溃疡患者给予奥美拉唑、呋喃唑酮及阿莫西林三联疗法，取得满意效果，现报告如下。 　　1? 资料与方法 　　1.1? 一般资料? 选择2000年1月~2005年12月在本院就诊均经胃镜检查，取胃黏膜活检尿素酶试验检测Hp阳性的消化性溃疡患者64例，治疗前1周内