降胆固醇治疗获益的新证据SHARP研究的启示.pptVIP

2010大规模荟萃分析： eGFR和蛋白尿与全因死亡及心血管死亡密切相关 基线血脂水平 慢性肾脏病患者降脂治疗临床研究小结 4%0.84-1.11 P 0.59 Rosuvastatin 10 mg/day 45.6 Time to a major cardiovascular event RCT n 2776, end-stage renal disease on maintenance hemodialysis AURORA3 17% 0.74 – 0.94 p 0.002 Simvastatin 20 mg/day + ezetimibe or 10 mg/day vs placebo 4.9yrs Major arthrosclerosis events coronary death, myocardial infarction, ischemic stroke and any revascularization procedure RCT n 9438, predialysis and dialysis SHARP 8%0.77-1.10 P 0.37 Atorvastatin 20 mg/day 48 Cardiac death, fatal stroke, NFMI, or stroke RCT n 1255, d