临床研究格列美脲联合二甲双胍短期内强化治疗对初诊2型糖….pdfVIP

·564 · 南方医科大学学报（J South Med Univ ） 2011;31(3) ·临床研究· 格列美脲联合二甲双胍短期内强化治疗对初诊2 型糖尿病疗效 的观察 1 2 2 2 2 2 汪 敏 ，高 方 ，薛耀明 ，韩亚娟 ，符霞军 ，何飞英 1 2 广州市胸科医院内分泌合并结核病科，广东广州510095 ；南方医科大学南方医院内分泌代谢科，广东广州 510515 摘要：目的对HbA 1c9%的新诊断的2 型糖尿病患者进行12周的口服药物短期强化治疗，观察强化方案的疗效。方法 对HbA 1c9%的新诊断的2 型糖尿病患者进行格列美脲联合二甲双胍12周的短期强化治疗，观察疗效。结果 治疗后 FPG、2 h PG、HbA 1c 均显著下降(P0.01) ；HOMA －IR 下降、HOMA －B 升高(P 均0.01) ；TG、CHOL、LDL 均显著下降(P 0.01)。结论 HbA 1c9%的新诊断的T2DM 患者格列美脲联合二甲双胍短期强化方案安全有效。 关键词：2 型糖尿病；强化治疗；格列美脲；胰岛β细胞功能；血脂 中图分类号：R587.1 文献标志码：A 文章编号：1673-4254（2011）03-0564-03 Effect of short-term intensive therapy with glimepiride and metformin in newly diagnosed type 2 diabetic patients 1 2 2 2 2 2 WANG Min , GAO Fang , XUE Yao-ming , HAN Ya-juan , FU Xia-jun , HE Fei-ying 1Department of Endocrinology and Tuberculosis, Guangzhou Chest Hospital, Guangzhou 510095, China; 2Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Abstract: Objective To evaluate the effect of short-term intensive therapy on blood glucose control, β-cell function, and blood lipid levels in newly diagnosed type 2 diabetic patients．Methods Out-patients with newly diagnosed type 2 diabetic patients were enrolled for intensive treatment with sulfonylureas and metformin for 12 weeks, and the therapeutic effect was evaluated. Results After the intensive treatment, FPG, 2 hPG, and HbA1c decreased significant