基因位置与肿瘤染色体易位的关系.pdf

肿瘤2012 年6 月第32 卷第6 期　TUM OR Vol. 32, J une 2012　　 475 DOI: 10.3781/j .issn.1000-7431.2012 .06.015 Copyright© 2012 by TUM OR 综述 Review · 基 因位置与肿瘤染色体易位的关系 郑　杰1 ，洪泽辉2 东南大学医学院　1. 病理学系 2 . 遗传与发育生物学系 教育部发育与疾病相关基因重点实验室 南京2 10009 ； ， ， [ 摘要 ]　染色体易位在肿瘤中很常见，但其发生的分子机制复杂，目前尚未完全阐明。近年的研究显示，细胞核 基因组的组织结构是高度有序的，每条染色体或染色质都有 自己的位置和领地，它们相互交错，共同维持着基因 转录网。肿瘤细胞染色体易位的非随机性被认为与间期核内染色体或基因的空间位置密切相关。染色体易位通常 发生在核内邻近的染色体或空间位置接近的基因。这些发现对肿瘤的早期诊断和靶向治疗具有重要意义。 [ 关键词 ]　肿瘤 染色体易位 基因位置 ； ； [中图分类号]　R730.231 [文献标志码] A [文章编号]　1000-7431 (2012) 06-475-05 Relationship between gene positioning and chromosomal translocation in cancer 1 2 ZHENG Jie , HONG Ze-hui 1. Department of Pathology; 2. Department of Genetics and Developmental Biology, Key Laboratory of Developmental Genes and Human Diseases of Ministry of Education, School of Medicine, Southeast University, Nanjing 210009, China [A BST RA CT ]　 Chromosomal translocations are very common in human cancer. The molecular mechanisms of chromosomal translocations are complex and unclear. Recent studies show that the organization of genomes is higher-order in the nucleus and every chromosome or chromatin has its preferential position and territory. Intermingling of chromosome territories in interphase maintains the transcriptional networks of genes. The spatial arrangements of chromosomes and gene loci in the interphase nucleus are responsible for nonrandom chromosomal translocations in human cancer. Chromosomal translocations are favored in neighbor chromosomes or genes in spatial proximity within the nucleus. These findings may lead to new approaches in early diagnosis and target therapy of cancer. [KEY WORDS]　 Neoplasms; Chromosomal translocation; Gene pos