精神分裂症COMT基因多态性与暴力行为的关联研究_刘文英.pdfVIP

2008 6 Jun, 2008 20 11 M d ical Journal of Chin s P opl s H alth Vo.l 20 FHM No. 11 COMT 刘文英, 周云飞, 高 欢, 吴怀安 , 518020 : COMT : PCR RFLP , 109 64 COMT , COMT: COMT COMT : COMT ; ; ; [ ] R749. 3 [ ] A [] 0369 2008 11- 1105- 03 A ssociation study of COMT gene polym orph ism and schizophren ia w ith aggressive behaviors LIU W n- y ing, ZHOU Yun- f i, GAO Huan, t al Kangning hospital of Sh nzh n, Sh nzh n 518020, China A bstract O bj ective: T o xplor th r lationsh ip b tw n COMT g n polym orph ism and sch izophr n ia w ith orw ithout aggr s- siv b haviors. M ethod s: 109 sch izophr niaw ith aggr ssiv b haviors and 64 schizophr n iaw ithout aggr ssiv b haviors w r r cru it d into th study. Th g n polym orph ism of COMT in all subj cts was g notyp d d ir ctly w ith polym ras chain r action PCR and r - striction fragm nt L ngth polym orph ism RFLP t chn iqu , and to com par th d iff r nc s of COMT polym orph ism b tw n schizo- phr niaw ith and w ithou t aggr ssiv b haviors. Resu lts: Th r w r no sign ificant d iff r nc s b tw n sch izophr n ia w ith and w ithout aggr ss iv b haviors in th fr qu nci s of g n for COMT. Th r w r no sign ifican t d iff r nc s am ong A /AA /G and G /G g n typ sch izophr n ia in th follow ing it m s: V rbal aggr ssion, aggr ssion tow ards prop rti s, s lf- aggr ssion, and phy sical aggr ssion to- w ards p op l and OA S total scor s. Con clu sion s: COMT g n s x rt no critical in flu nc in sch izophr n ia w ith and w ithout aggr ssiv b haviors. K ey w ordsSch izophr n ia; Aggr ssiv b haviors; Cat chol- O- m thyltransf ras ; G n tic polymorph ism DSM - IV 173 [