expressions of matrix metalloproteinases and tissue inhibitor of metalloproteinases after bare and magnetic stent implantation in rabbits期刊.pdfVIP
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J our nal of Ger i at r i c Car di ol o gy J une 2008 Vol 5 No 2 1 1 1
Labor at or y Res ear ch
Ex r e s si ons of mat r i x met al l o r ot ei nas es and t i s s ue i nhi bi t or
of met a ¨o r ot ei nas es a f t er bar e and magnet i c st ent
i m l ant at i on i n r abbi t s
Xi nhong Gu0 1,Guol i ang J i a2 ,Anl i n Lu2,Xi nguo Zh a02,Fe i Li 2 ,
Rongqi ng Zhan92
』I nst i t u t e of Ger i at r i c Car di ol ogy,Chi ne se PLAGener al Ho s i t a l ,Beij i n g 100853 ,Chi na
2 De ar t ment ofCar di ol ogy ,Xij i ng Ho s i t al ,Xi ’a n 7 10033 ,Chi na
obj e e t i v e We ai me d t o i nvest i gat e whet her ma gne t i c s t ent has r eve nt i ve e f fect on i n—s t ent r est enos i s by ob se r vi ng ex r ess i ons of
mar x met al i o r ot ei na s e( MMP) 2 ,MMP9.t i ss ue i nhi bi t or of mamx met a l l o r ot e i na se ( TI MP) l and TI MP2 af t er ba l l oon angi o l a s t y ,
ba r e an d ma gnet i c s t ent i m l ant at i on i n r abb i t s . Met hod s Ra bb i t s underwent bal l oon angi o l as t y .bar e a nd ma gne t i c s t ent i m l ant at i on
i n t he l e ft i l i a c ar t er i es .The c han ges of MMPs a nd T1MPs wer e e xami ned a t var i ous t i me oi nt s i n t he i nj ur ed art er i es us i ng t he met hods
of zymogr a hy.We s t em bl ot anal ys i s .r ever s e t r anscr i t i on— ol y mer as e ch ai n r ea ct i on( RT.PCR) a nd mor homemc a na ly s i s . Res ul t s
Ba l l oon ang i o l as t y gr ou ( BA) and magnet i c
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