overproduction of nitrate and s-nitrosothiols in diabetic patients期刊.pdfVIP

Jo uo al of Ge血介止‘Ca n五d掬吸v March 2008 Vol 5 No l 2 5 C五儿ic al Researc h o ver Pr oduction of nitr ate and S一nitr osothiols in diabetic Patients J unPing Zhao ，Chengbin 自ng，Hongli TO ng，uY zhen Li，Chun劝Zhou ， Ya Ping Tian ，Sh iwei Liu Gene ra l HoPs ita l of hC inese PLA，Beji nig I 008j 3，hC ina. o jh ce 柱ve hT e Pre sent sut dy was designde to investi gate changes in seur m or Plasma concentrta ions of nitri c oxide and its deri vtia ves ni id abe tic Patients . Meht do s Seur m nirt ate co nce nrt ation of 48 diabe ti c Ptia ne ts was meas urde by using na enZyme ki neti c meht do ，and ht e Plasma S一nirtO soht iols concentrta ion of l 0 cas es was measure d by using HPLC tce hnique . Results s eur m nitrtae concentration na d Plasma S一ni rto sothiols co nce ntrta ion in ht e diabeti cs were signiif cna tly higher ht na in conrto l gro uP (尸0.ol na d 尸丈0.05 ，re spe cti vely). hT e serum ni trate co nce ntration in diabe tics la so hda a signi if cna t po sitive crroe Itia on wiht hte serum glucoes concentratino (R习.7256，P0.05 )，but hti s con ℃ltia on was nto of und in conrto l rg ouP. Co. lc usion hT ese data showde that N0 na d its drie vtia ves rae ovepr rdo ucde ni ht e diabe tic Ptia ents .J( Ge对渔介 恤〔州物12侧)8; 5:25 一2)7 Key w drds S一ni tro soht iols; ni rti c oxide ; id abe tics 48 diabe ti c Ptia ents (48 mla es na d 36 ef mla es)，wiht na mena I n t r o d u c t i on ga e of 47.s yeras (25一7l yeras ) wree enro