抗HIV药物筛选中靶点和筛选模型研究现状.pdfVIP

VIROLOGICA SINICA, December 2007, 22 (6):476-485 CLC number: R511 Document code: A Article ID: 1674-0769(2007)06-0476-10 Current Status of Targets and Assays for Anti-HIV Drug Screening Ren-rong TIAN, Qing-jiao LIAO and Xu-lin CHEN** (State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China) Abstract ：HIV/AIDS is one of the most serious public health challenges globally. Despite the great efforts that are being devoted to prevent, treat and to better understand the disease, it is one of the main causes of morbidity and mortality worldwide. Currently, there are 30 drugs or combinations of drugs approved by FDA. Because of the side-effects, price and drug resistance, it is essential to discover new targets, to develop new technology and to find new anti-HIV drugs. This review summarizes the major targets and assays currently used in anti-HIV drug screening. Key words: Anti-HIV; Targets; Assays; Drug screening Since the discovery of Human immunodeficiency are 7 combinations of drugs currently approved by virus (HIV) and acquired immunodeficiency syndrome FDA. Additional agents are in various stages of (AIDS) in 1981 (50), this disease has become one of clinical and preclinical development. the most significant public health challenges globally. HIV/AIDS have claimed the lives of more than 25 THE LIFE CYCLE OF HIV million people worldwide. The year 2006 marks the HIV-1 is an enveloped virus that contains two 10th anniversity of the introduction of highly active copies of viral genomic RNA in its core. The antiretroviral therapy (HAART), a combination of approximatel