现代生物学对药物发现影响_郭家彬.pdfVIP

2007 38 1 # 25# * 郭家彬 李学军v (, 100083) 随着后基因组时代的到来, 药物发现研究领域不断涌现出一系列新思路新技术新 法, 从 而迅速推进药物发现的多元化发展 一 面, 基因组学蛋白质组学转录组学代谢组学生物信 息学系统生物学等新兴学科的崛起与发展, 为药物发现提供更为广泛而深刻的理论基础; 另 一 面, 计算机辅助药物设计高通量筛选高内涵筛选生物芯片转基因和 RNA 干扰等高新技术的发 展和完善, 为药物发现提供了新的技术手段和有力工具, 极大地拓宽了药物发现的途径本文结合 近年来现代生物学的研究进展, 综述现代生物学对药物发现过程的影响 药物发现; 现代生物学; 药物靶点; 药物筛选 R96 Im pacts of M odern B iology on D rug D iscovery GUO Jia-Bin, LIXue-Jun (D ep artm ent of P harm a- cology, P ek ing Un ivers ity H ealth Science C enter, Beijing 100083, C ina) Abs tract D rug discovery as been mi proved greatly by series of new ideas and new tec nologies asw ell as new approac es emerging in t e postgenom ic era. On t e one and, t e t eoretics of drug d iscovery become more compre ensive andmore profound as t e development of num erous new d isciplines suc as genom ics, proteom ics, transcriptom ics, metabonom ics, b ioinformatics and system b iology; on t e ot er and, t e pat w ays for new drug d iscovery are broadened by t e continuous mi provem ent of tec nological platform s includ ing computer-aided drug design, ig t roug put screen ing, ig content screening, b io- c ip, transgen ic and RNA i tec nology. Based on t e recent advances on t emodern b iology, in t is art-i cle, w e specially review ed t e mi pacts ofmodern biology on t e process of drug d iscovery. K ey w ord s drug d iscovery; modern b iology; drug target; drug screen ing , , ; ( N ew Compound , Entities, NCEs) RNA 20 80, , ,