Sirt1一种新的脂肪细胞和肌细胞调控因子.pdfVIP

遗 传 HEREDITAS (Beijing) 28(11): 1462~1466, 2006 专论与综述 DOI: 10.1360/yc-006-1462 Sirt1: 一种新的脂肪细胞和肌细胞调控因子 白 亮, 庞卫军, 杨公社 (西北农林科技大学动物脂肪沉积与肌肉发育实验室, 陕西 杨凌 712100) + 摘 要: Sirt1(Sirtuin type 1)是依赖于烟酰胺腺嘌呤二核苷酸(NAD )的组蛋白脱乙酰酶, 为 Sirtuins 家族成员之一, 与 细胞增殖、分化、衰老、凋亡和代谢密切相关。目前, 有关 Sirt1 与衰老和代谢的论文已在 Science、Nature 、Cell 等杂志上连续刊出。其中, Sirt1 通过抑制 PPARγ 促进白色脂肪细胞中脂肪动员, 并且通过下调肌细胞标志基因表 达来抑制成肌细胞分化。提示 Sirt1 不仅是一个重要的与机体“长寿”有关的因子, 而且可能在动物脂肪沉积和肌肉 发育中起着关键的调控作用。 关键词: Sirt1 基因; 长寿; 脂肪细胞; 成肌细胞; 细胞分化 中图分类号: Q25 文献标识码: A 文章编号: 0253-9772(2006)11-1462-05 Sirt1: A Novel Adipocyte and Myocyte Regulatory Factor BAI Liang, PANG Wei-Jun, YANG Gong-She (Laboratory of Animal Fat Deposition and Muscle Development, Northwest AF University, Yangling 712100, China) Abstract: Sirt1 (Sirtuin type 1), a member of the conserved sirtuin family, is a NAD+ -dependent histone deacetylase. It is intimately related to cell proliferation, differentiation, apoptosis, and metabolism. Its role in senescence and metabolism has recently come to light. Sirt1 promotes fat mobilization in white adipocytes by repressing PPARγ and inhibits myoblast differentiation by down-regulating muscle gene expression. Therefore, Sirt1 is not only an important longevity factor, but also may play a key modulatory role in animal fat deposition and muscle development. Key words: Sirt1 gene; longevity; adipocyte; myoblast; cell differentiation Sirt1 是酵母染色质沉默因子Sir2 (Silent informa-