肉桂酸的合成及其二聚反应的研究66216.pdfVIP

第36 卷第2 期 Vol. 36 No. 2 2008 年4 月 JOURNAL OF ZHEJIANG UNIVERSITY OF TECH NOLOGY Apr . 2008 , , , , ( , 3 0032) : 利用Knoevenagel 反应合成肉桂酸, 研究了吡啶和六氢吡啶的用量阻聚剂及反应时间对 率的 影响, 确定了最佳的反应条件, 苯甲醛丙二酸吡啶六氢吡啶的摩尔比为5 6 2 0. 67, 在95 ! 下回流反应2 h, 肉桂酸的 率可达到83. 7%. 该方法工艺简单, 率高, 反应无污染, 物易分离纯 化. 同时利用光化学反应合成了天然提取物古柯间二酸, 为肉桂酸的进一步开发利用提供了途径. : Knoevenagel 反应; 肉桂酸; 古柯间二酸; 二聚反应 : O62 . 3 : A : 0064303( 2008) 020 5503 Study on synthesis of cinnamic acid and its dimeric reaction QI Jingyun, WANG Hong, CHEN Hongfeng, HE Pan, QIANG Genrong ( College of Chemical Engineering and M aterials Science, Zhejiang University of Technology, H angzhou 3 0032, China) Abstract: Cinnamic acid w as synthesized by the Knoevenagel reaction. In this paper , the impor tant effects on the reaction, such as the molar ratio of pyridine and hexahydropyridine, the addi tion of antipolymeriztion reagent and the reaction time w ere discussed. The results indicated that the highest yieid ( 83. 7% ) can be obtained w hen the ratio of benzaldehyde, malonic acid, pyridine and hexahydropyridine w as 5 6 2 0. 67, the reaction temperature w as 95 ! and the reac tion time w as about 2 hours. T his method has many advantages, such as high yield, easy opera tion and purification. In the meantime, the natural product truxillic acid w as synthesized by the photochemistry reaction, w hich gives a new application of cinnamic acid. Key words: Knoevenagel reaction; cinnamic acid; truxillic acid; dimeric reaction ( 2, 4 0 ) , , [ 4]