舒络抗脑缺血与降压作用研究.pdfVIP

医药导报2009年8月第28卷第8期 ·993 · 舒络抗脑缺血与降压作用研究 马小亚,王美纳,王玉虎,梁维薇 (西安交通大学医学院第二附属医院临床药理研究室,710004) [摘摇 要]摇 目的摇 研究舒络的抗脑缺血作用和对自发性高血压大鼠(SHR)血压的影响。 方法摇 采用阻断大鼠一 侧大脑中动脉造成局灶性脑缺血模型,观察舒络对缺血大鼠的脑梗死范围、组织病理学和脑组织丙二醛(MDA)含量的 -1 影响;尾动脉容积法测定清醒SHR动脉收缩压(SBP)。 结果摇 大鼠缺血24 h后,舒络(1.00,0.50 g ·kg ,ig)能显著缩 小脑梗死范围,减轻脑组织病理性损伤,并且明显降低脑组织MDA含量;舒络亦可降低 SHR 的SBP。 结论摇 舒络对大 鼠局灶性脑缺血损伤具有保护作用,并能有效降低SHR血压。 [关键词]摇 舒络;脑缺血;高血压 [中图分类号]摇 R286;R544 摇 摇 摇 [文献标识码]摇 A摇 摇 摇 [文章编号]摇 1004鄄0781(2009)08鄄0993鄄03 Anti鄄cerebral Ischemia and Antihypertensive Effects of Shuluo MA Xiao鄄ya,WANG Mei鄄na,WANG Yu鄄hu,LIANG Wei鄄wei (Department of Clinical Pharmacology, the SecondAffiliated Hospital,School of Medicine,Xian Jiaotong University,Xian710004,China) ABSTRACT摇 Objective摇 To study the effects of shuluo on focal cerebral ischemia in rats and blood pressure in spontaneously hypertensive rats (SHR). 摇 Methods摇 Thefocal cerebral ischemia model was produced by permanent occluding the right middle cerebral artery (MCAO). The infarct area, contents of malondihyde (MDA) in cerebrum and brain histopathology were examined.Systolic blood pressure (SBP) was measured in conscious SHR by tail鄄cuff method. 摇 Results摇 鄄1 Shuluo (1.00 and0.50 g ·kg ,ig) significantly decreased the infarct area and contents of MDA after MCAOfor24 h in rats. Shuluo markedly ameliorated the ischemia injury of braintissue and decreased SBP in SHR.摇 Conclusion摇 Shuluo not only has protective effects on focal cerebral ischemia in rats ,but also decreases the blood pressure in SHR. KEY WORDS摇 Shuluo;Cerebral ischemia;Hypertension 摇 摇 高血压与脑卒中关系密切,脑卒中是人群主要的 平片(正大青春宝药业有限公司提供,每片20 mg,批 病残和死亡原因。